Estradiol
Disclaimer: Information on this page is for educational purposes. Consult a physician to interpret your test results. Lissa Health helps track biomarker trends but does not replace medical advice.
What This Test Measures
Estradiol (E2) is the primary estrogen regulating menstrual cycle and bone density in women.
Levels vary by cycle phase — cycle day must be noted.
In postmenopausal women, excess estradiol may indicate obesity or tumors.
Normal Ranges
| Group | Reference Range |
|---|---|
| Men | 10–40 pg/mL (40–160 pmol/L) |
| Women | Cycle phase dependent |
| Children | Age dependent |
Reference ranges may vary by laboratory and assay method.
Causes of High Levels
- Ovarian tumors
- Obesity
- Liver cirrhosis
- Exogenous estrogen
Causes of Low Levels
- Menopause
- Primary ovarian insufficiency
- Hypogonadism
- Anorexia
Test Preparation
- Women — note cycle day
- Fasting preferred
- Report HRT use
Related Biomarkers
| Biomarker | Relationship |
|---|---|
| Testosterone | Balance |
| Prolactin | Pituitary-gonadal axis |
| Thyroid Stimulating Hormone (TSH) | Metabolic interaction |
FAQ
How often should I take this test?
For infertility/menopause — as directed.
What should I do if my result is abnormal?
Unexpected elevation in men — evaluate liver disease, obesity, or estrogen-secreting tumor.
Last updated: June 2026