Total Bilirubin
Disclaimer: Information on this page is for educational purposes. Consult a physician to interpret your test results. Lissa Health helps track biomarker trends but does not replace medical advice.
What This Test Measures
Total bilirubin is a breakdown product of hemoglobin. Elevation causes jaundice and indicates impaired hepatic bilirubin metabolism or increased hemolysis.
Bilirubin includes indirect (unconjugated) and direct (conjugated) fractions. Their ratio helps determine the cause of hyperbilirubinemia.
Physiologic neonatal jaundice is common; in adults, elevation requires thorough evaluation.
Normal Ranges
| Group | Reference Range |
|---|---|
| Men | 0.2–1.2 mg/dL (3.4–20.5 µmol/L) |
| Women | 0.2–1.2 mg/dL |
| Children | 0.2–1.2 mg/dL |
Reference ranges may vary by laboratory and assay method.
Causes of High Levels
- Hepatitis and cirrhosis
- Obstructive jaundice (cholangitis, gallstones)
- Hemolytic anemia
- Gilbert syndrome
- Crigler-Najjar syndrome
Causes of Low Levels
- Rarely clinically significant
- Certain lab artifacts
Test Preparation
- Fasting preferred
- Avoid alcohol beforehand
- Report skin or eye yellowing
Related Biomarkers
| Biomarker | Relationship |
|---|---|
| Direct Bilirubin | Differentiate jaundice causes |
| Alanine Aminotransferase (ALT) | Liver injury |
| Alkaline Phosphatase | Cholestasis |
FAQ
How often should I take this test?
Immediately with jaundice symptoms; with chronic liver disease — every 3–6 months.
What should I do if my result is abnormal?
Elevation with jaundice, dark urine, or pale stools — urgent medical evaluation.
Last updated: June 2026