Coagulation Panel

The coagulation panel evaluates the body's ability to form and dissolve blood clots. These tests are ordered before surgery, when thrombosis or bleeding is suspected, and to monitor anticoagulant therapy.

Disclaimer. Coagulation results require clinical context — a single marker rarely tells the full story.

Key Markers

Fibrinogen

A protein involved in clot formation. Elevated during inflammation, trauma, and pregnancy; decreased in DIC and severe liver disease.

D-Dimer

A breakdown product of clots. Elevation may indicate thrombosis but also occurs in pregnancy, after surgery, and during inflammation.

Prothrombin Time (PT)

Time for clot formation in the first stage of coagulation. Used to monitor anticoagulant therapy and liver synthetic function. Often reported as INR.

When Ordered

• Pre-operative assessment
• Suspected deep vein thrombosis or pulmonary embolism
• Unexplained bleeding or bruising
• Monitoring anticoagulant medications
• Pregnancy with thrombosis risk factors
• Inherited clotting disorders

Preparation

• Usually collected fasting.
• Tell your doctor about all medications — especially anticoagulants, aspirin, and NSAIDs.
• If taking anticoagulants, confirm timing of your last dose.

See also: Complete Blood Count · Biomarker Catalog